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I switched from Zoloft to generic zoloft six weeks ago and have definitely regressed. I have been on Zoloft and Wellbutrin for 3 years and had remakable improvement. I am 61 years old and after six weeks on the generic drug, I am feeling more depressed than I have been for the past three years and now also have dificulty getting to sleep and/or staying asleep. I am going to try to get back on the regular Zoloft again, depending on my insurance company approving it. I have also lost weight over the same six week period. I would not suggest anyone make the switch to the generic brand

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Zoloft (generic name sertraline) is one of the most widely prescribed anti-depression drugs in the world. The number of people suffering from Zoloft side effects is unknown, as many people may not even be aware that certain physical/emotional/mental Zoloft side effects even exist. Zoloft belongs to a group of drugs known as Selective Serotonin Reuptake Inhibitors (SSRIs). Almost all reported Zoloft side effects meet the same profile as side effects caused by other SSRIs, although the general public remains in many cases unaware of potentially lethal Zoloft side effects, such as suicide, as well as the repercussions of taking other SSRIs. The most common Zoloft side effects, according to the Zoloft web site are dry mouth, upset stomach, decreased appetite, fatigue, trouble sleeping, sexual dysfunction, diarrhea, tremor, feelings of agitation, indigestion, and increased perspiration. Any Zoloft side effects may appear more pronounced in children, who are also susceptible to such Zoloft side effects as excessive movement or twitching, malaise, trouble concentrating, abnormal thinking, nosebleeds, weight loss, manic or excited behavior, or rapid mood swings. These Zoloft side effects are similar to those experienced when taking any form of medication, but some Zoloft side effects are less frequently mentioned, and tend to be more frightening in nature. Among the more serious Zoloft side effects are anxiety, liver problems/failure, convulsions, hallucinations, psychosis and mania. Although many individuals feel that Pfizer does not provide sufficient warning about all the potential Zoloft side effects, especially those that are more severe or life-threatening. In addition to the Zoloft side effects that occur while taking the drug, patients who have decided to stop treatment have found that the Zoloft side effects resulting from withdrawal can be even worse. Although all SSRIs carry the risk of withdrawal, with Paxil's among the worst, Zoloft side effects tend to rank as a close second. Patients who have stopped taking the drug have reported Zoloft side effects from withdrawal that include jolting electric "zaps", dizziness, extreme nausea and vomiting, high fever, abdominal discomfort, flu symptoms, agitation, anxiety, insomnia, aggression, nightmares, tremor, seizure, and confusion. The Zoloft side effects stemming from withdrawal can become so painful that some patients have committed suicide to end their misery. A more common result of Zoloft withdrawal is misinterpretation by the physician and/or patient, with a wrongful diagnosis of regression. If you or a loved one is experiencing Zoloft side effects, you should immediately consult a physician to fully discuss your medical options. The Zoloft side effects can become much worse if you stop taking the medication abruptly. Persons who have suffered from Zoloft side effects may be entitled to recover funds for the medical costs, pain and suffering, and punitive damages. Consulting an attorney who has worked with persons experiencing Zoloft side effects in the past is highly recommended. For more information on the side effects of Zoloft, please contact us to speak with a lawyer.

December 5, 2006: FDA to Review Suicide Risk for Young Adults Taking Antidepressants The U.S. Food and Drug Administration (FDA) announced a December 13 meeting of outside medical experts who will consider new data on the increased risk of "suicidality" (suicidal thinking and behavior) in young adults taking antidepressant medications. This meeting is a follow-up to two meetings on antidepressants and suicidality in pediatric patients held in February and September, 2004. The FDA states that it plans to modify antidepressant drug labels based on the panel's findings. July 2006: Combined Use of Zoloft and Migraine Medicines Risky The U.S. Food and Drug Administration (FDA) issued a public health advisory concerning the use of Zoloft and other antidepressants. The FDA announced the risks associated with the combined use of selective serotonin reuptake inhibitors (SSRIs, such as Zoloft) and triptans (used to treat migraine headaches). Combined use can lead to a life-threatening condition called serotonin syndrome. Click here to read more. July 2006: Treatment Challenges of Depression in Pregnancy The FDA issued a public health advisory about the potential risks of using Zoloft and other antidepressants during pregnancy. The FDA announced the results of a study examining the use of antidepressant medicines during pregnancy by mothers of babies born with a serious condition called persistent pulmonary hypertension of the newborn (PPHN). Babies born with PPHN have abnormal blood flow through the heart and lungs, and do not get enough oxygen to their bodies. Click here to read more.

What is Zoloft? Zoloft has the generic name of sertraline HCI and is marketed by Pfizer Inc. Zoloft belongs to a class of drugs known as selective serotonin reuptake inhibitors, more commonly referred to as SSRIs. The class of SSRIs includes other widely prescribed antidepressants such as Prozac and Paxil. Zoloft is prescribed to treat a number of ailments including depression, anxiety disorders and obsessive-compulsive disorder (OCD). Depression can be an extremely debilitating problem, resulting in feelings of great sadness and sense of worthlessness. Some studies have shown that depression may be caused by an imbalance of the neurotransmitter brain chemical known as serotonin. Zoloft is designed to enhance the use of serotonin in the brain to improve the sending of nerve impulses, in the hopes of treating symptoms of depression.

(Newser) – Maybe you're feeling a little down—not to worry! Turn to self-help books, psychiatrists, little blue pills, or Dr. Phil to make you happier! But in Against Happiness, melancholy Eric Wilson rails against our culture’s “craven disregard for the value of sadness.” And a growing wave of morose-minded thinkers is joining the anti-happiness bandwagon, Newsweek reports. Thanks to modern society, sadness has become a disease to be treated, with plenty of perfectly normal human reactions falling under the clinical definition of depression. But like all emotions, melancholy has an evolutionary purpose, driving exploration and change. Since Aristotle, great minds have been driven by unhappiness to rethink the status quo. “The happy man is a hollow man,” Wilson muses.

Injured by Zoloft? On December 13, 2006, the FDA announced antidepressants prescribed to young adults are risky. The agency proposed expanding the labels of all antidepressants to include an expanded warning of suicidal thoughts in patients ranging from 18-24 years of age. The newly presented change would expand a warning now on the labels that pertain only to children and adolescents treated with antidepressant drugs. The new label changes would also contain a suggestion that patients of all ages be carefully monitored, particularly when starting antidepressant treatment. The FDA recently completed a bulk evaluation of 372 studies involving approximately 100,000 patients and 11 antidepressants, including Lexapro, Zoloft, Prozac and Paxil. When the results are analyzed by age, it becomes clear there is an elevated risk for suicidal thoughts and behavior among adults 18 to 25 that approaches that seen in children, the FDA said in documents released before their scheduled December 13, 2006 meeting of its psychopharmacologic drugs advisory committee. In May 2006, GlaxoSmithKline and the FDA cautioned Paxil may raise the risk of suicidal behavior in young adults too and changed the drug’s label to reflect that risk. The FDA has recently urged the makers of Zoloft and other SSRI antidepressants to add a warning about suicidal behavior. The FDA stated that patients using Zoloft and other antidepressants should be watched closely for suicidal tendencies. The FDA advisory panel suggested the new warnings after an emotional hearing with testimony from the parents of children and teenagers who attempted suicide or took their own lives after starting antidepressants. The expanded warnings on antidepressant labels advise health-care providers to "carefully monitor patients receiving antidepressants for possible worsening of depression or suicidality, especially at the beginning of therapy or when the dose either decreases or increases."

Antidepressant Studies Distort Drugs' Usefulness Jan 16, 08 9:37 PM CST (Newser) - Roughly half of the medical studies involving antidepressants that found little or no effect on patients have gone unpublished or had their findings mischaracterized as positive, a new study reveals. The emphasis on publishing only studies with glowing reviews gives patients and doctors a false sense of the effectiveness of drugs such as Zoloft and Effexor, the Wall Street Journal reports. More »

In June 2001, a jury in Wyoming determined that the antidepressant drug Paxil caused a man to kill his wife, daughter and granddaughter before killing himself. The jury awarded the surviving family $8 million in damages, according to American Medical Publishing's Prescription Medicines, Side Effects and Natural Alternatives. In Portland, Ore., Jay Johnston followed his doctor's orders and took the prescribed antidepressants Zoloft and Prozac. He then attempted suicide with a shotgun, permanently disfiguring himself. In the same month as the Wyoming jury's decision, Johnston sued his doctor for not properly monitoring him. The jury found the doctor guilty of criminal negligence and awarded Johnston $5 million, reports Dr. Ann Blake Tracy in Prozac: Panacea or Pandora. Similarly, who could forget Eric Harris, who -- along with Dylan Klebold -- killed 11 people and then himself in the Columbine school shooting? At the time of the shooting, Harris was being treated with the prescription antidepressant Luvox. These patients are among the growing statistics of people who committed suicide, or tried to commit suicide, while undergoing treatment with prescription antidepressants. Antidepressant drugs such as Prozac, Luvox and Paxil are selective serotonin reuptake inhibitors, commonly known as SSRIs. Serotonin is one of your brain's most important biochemicals; it controls everything from appetite to mood swings. If you're depressed, compulsively eating or gambling, not sleeping properly or even just moody, you're probably lacking serotonin. It's important to note, however, that you can also have too much serotonin. In Health and Nutrition Secrets, Dr. Russell L. Blaylock writes, "It is also known that these medications increase brain levels of the neurotransmitter serotonin, which, in high concentrations, can also act as an excitotoxin." When antidepressant drugs raise serotonin to an excitotoxin level, the brain reacts in ways similar to mental illness. According to Burton Goldberg's book, Alternative Medicine, side effects of SSRIs include uncontrollable facial and body tics, dizziness, hallucinations, nausea, sexual dysfunction, addiction, electric-shock-like sensations in the brain and, of course, homicidal or suicidal thoughts and behavior. Unfortunately, the doctors prescribing these SSRIs often forget that you can have too much of a good thing -- that is, too much serotonin -- so they prescribe SSRIs to just about everyone. Now, there are some truly bad doctors out there, such as the psychiatrist whom Dr. Joseph Glenmullen describes in Prozac Backlash: "Anna was started on Prozac but became severely anxious, agitated and sleepless ... Having never been suicidal before, two weeks after starting Prozac, Anna went to her HMO because she felt like killing herself. The psychiatrist on call told Anna the Prozac was indeed making her worse and hospitalized her. But her original psychiatrist disagreed, restarted Prozac, although at a lower dose and added a second, sedating antidepressant (Trazodone), which Anna only took for two days." Anna's original doctor seems to be little more than a licensed drug dealer. However, let's give the benefit of the doubt to most antidepressant-prescribing doctors and say that they're just ignorant of antidepressants' potentially fatal side effects. Based on Goldberg's figures, physicians -- not psychiatrists -- write over 70 percent of all prescriptions for SSRIs, so they may very well be ignorant of the antidepressant scare.

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